FGF Is Required for Posterior Neural Patterning but Not for Neural Induction
نویسندگان
چکیده
منابع مشابه
FGF/MAPK signaling is required in the gastrula epiblast for avian neural crest induction.
Neural crest induction involves the combinatorial inputs of the FGF, BMP and Wnt signaling pathways. Recently, a two-step model has emerged where BMP attenuation and Wnt activation induces the neural crest during gastrulation, whereas activation of both pathways maintains the population during neurulation. FGF is proposed to act indirectly during the inductive phase by activating Wnt ligand exp...
متن کاملPosteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction.
The neural crest is a unique cell population induced at the lateral border of the neural plate. Neural crest is not produced at the anterior border of the neural plate, which is fated to become forebrain. Here, the roles of BMPs, FGFs, Wnts, and retinoic acid signaling in neural crest induction were analyzed by using an assay developed for investigating the posteriorization of the neural plate....
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In the embryonic telencephalon, Pax6 is expressed in the progenitors of the pallium in a caudal to rostral gradient and governs the anteroposterior and dorsoventral patterning of the telencephalon. The pallial–subpallial boundary (PSPB) is both a physical and gene expression boundary separating dorsal and ventral telencephalon. Previous studies have indicated that Pax6 is required for establish...
متن کاملEndothelial cell FGF signaling is required for injury response but not for vascular homeostasis.
Endothelial cells (ECs) express fibroblast growth factor receptors (FGFRs) and are exquisitely sensitive to FGF signals. However, whether the EC or another vascular cell type requires FGF signaling during development, homeostasis, and response to injury is not known. Here, we show that Flk1-Cre or Tie2-Cre mediated deletion of FGFR1 and FGFR2 (Fgfr1/2(Flk1-Cre) or Fgfr1/2(Tie2-Cre) mice), which...
متن کاملApoptosis is not required for mammalian neural tube closure.
Apoptotic cell death occurs in many tissues during embryonic development and appears to be essential for processes including digit formation and cardiac outflow tract remodeling. Studies in the chick suggest a requirement for apoptosis during neurulation, because inhibition of caspase activity was found to prevent neural tube closure. In mice, excessive apoptosis occurs in association with fail...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 1999
ISSN: 0012-1606
DOI: 10.1006/dbio.1998.9108