Fetotoxicity and neural tube defects in CD1 mice exposed to the mycotoxin fumonisin B1
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چکیده
منابع مشابه
Effects of long term exposure to the mycotoxin fumonisin B1 in p53 heterozygous and p53 homozygous transgenic mice.
The fungal toxin fumonisin B1 (FB1) is a potential human carcinogen based on evidence of renal carcinogenicity in rats and hepatocarcinogenicity in mice. The toxicity and carcinogenicity of FB1 is linked to ceramide synthase inhibition. Based on this mechanism of action and on lack of evidence of genotoxicity, FB1 is considered a non-genotoxic carcinogen. The p53 heterozygous (p53+/-) mouse is ...
متن کاملبررسی میزان جذب فومونیزین B1 توسط نانوذرات سلولز اصلاح شده با پلی لیزین در حضور مواد غذایی مختلف
Introduction: Fumonisin B1 is a mycotoxin which can lead to neural defects, esophageal cancer, liver and kidney diseases. The aim of this study was to investigate the ability of nanocellulose conjugated with poly-lysine to remove fumonisin B1 in the different foodstuffs. Methods: First, nanocellulose was synthesized by acid hydrolysis, modified by citric acid, and conjugated with poly-lysine b...
متن کاملMycotoxin fumonisin B1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs.
Fumonisin B1 (FB1), a mycotoxin produced by Fusarium verticillioides, may contaminate feed and food. In the present study, we investigated the effect of FB1 on the modulation of the cytokine profile and on the establishment of a vaccinal antibody response. In vitro investigations on pig peripheral blood mononuclear cells (PBMC) indicate that FB1 decreased interleukin-4 (IL-4) and increased inte...
متن کاملThe mycotoxin fumonisin B1 alters the proliferation and the barrier function of porcine intestinal epithelial cells.
Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium verticillioides (formerly F. moniliforme), a fungus that commonly contaminates maize. FB1 causes toxicological effects in laboratory and domestic animals including pigs. Because the gastrointestinal tract represents the first barrier met by exogenous food compounds, the purpose of this study was to investigate the effects of FB1 on IPEC-1, ...
متن کاملReproductive and sphingolipid metabolic effects of fumonisin B(1) and its alkaline hydrolysis product in LM/Bc mice: hydrolyzed fumonisin B(1) did not cause neural tube defects.
Fumonisins are mycotoxins produced by Fusarium verticillioides. They are toxic to animals and exert their effects through mechanisms involving disruption of sphingolipid metabolism. Fumonisins are converted to their hydrolyzed analogs by alkaline cooking (nixtamalization). Both fumonisins and hydrolyzed fumonisins are found in nixtamalized foods such as tortillas, and consumption of tortillas h...
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ژورنال
عنوان ژورنال: Mycotoxins
سال: 2006
ISSN: 0285-1466,1881-0128
DOI: 10.2520/myco1975.2006.suppl4_67