Fertility-Sparing Surgery for Early-Stage Cervical Cancer: A Systematic Review of the Literature
نویسندگان
چکیده
ObjectiveThis systematic review aimed to evaluate oncologic and reproductive outcomes after fertility-sparing surgery (FSS) for early-stage cervical cancer (early CC).Data SourcesOvid MEDLINE, Ovid EMBASE, Cochrane CENTRAL were searched from 1980 the present using Medical Subject Headings terms; other controlled vocabulary keywords related fertility, cancer, surgical techniques.Methods of Study SelectionA total 2415 studies screened, with 53 included. Studies reporting recurrences a median follow-up 12 months in early CC (International Federation Gynecology Obstetrics 2009 stages IA lymphovascular space invasion, IB, or IIA) traditional histologic type undergoing FSS included.Tabulation, Integration, ResultsThe grouped by intervention, including vaginal radical trachelectomy (VRT), abdominal (ART), minimally invasive (MIS-RT), conization simple (ST), involving neoadjuvant chemotherapy (NACT). Combined rates recurrence (RR), death (CDR), pregnancy (PR), live birth (LBR) calculated per procedure on basis all included that reported procedure.The results as follows:VRT: RR 4%, CDR 1.7%, PR 49.4%, LBR 65.0%ART: 3.9%, 1.4%, 43.2%, 44.0%MIS-RT: 4.2%, 0.7%, 36.2%, 57.1%Cone ST: 0.8%, 55.1%, 71.9%NACT: 7.5% 2.0%ConclusionFSS VRT, ART, MIS-RT have comparable carefully selected patients, favoring VRT. Data nonradical cone ST are less robust but support similar fewer complications. NACT this setting requires more investigation before routine implementation into practice.
منابع مشابه
Fertility-Sparing Surgery for Early-Stage Cervical Cancer
Nowadays cervical cancer is diagnosed in many women who still want to have children. This led to the need to provide fertility-sparing treatments. The main goal is to maintain reproductive ability without decreasing overall and recurrence-free survival. In this article, we review data on procedures for fertility preservation, namely, vaginal and abdominal trachelectomy, less invasive surgery an...
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BACKGROUND There is as yet limited evidence about fertility-sparing surgery for early ovarian cancer (EOC) carried out laparoscopically. We sought to analyze recurrence patterns and fertility outcome in a cohort of ovarian cancer patients who underwent fertility-saving laparoscopic surgical staging. METHODS We conducted a retrospective analysis of prospectively collected data on all patients ...
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OBJECTIVE Fertility sparing surgery (FSS) is a strategy often considered in young patients with early epithelial ovarian cancer. We investigated the role and the outcomes of FSS in eEOC patients who underwent comprehensive surgery. METHODS From January 2003 to January 2011, 24 patients underwent fertility sparing surgery. Eighteen were one-to-one matched and balanced for stage, histologic typ...
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ژورنال
عنوان ژورنال: Journal of Minimally Invasive Gynecology
سال: 2021
ISSN: ['1553-4650', '1553-4669']
DOI: https://doi.org/10.1016/j.jmig.2020.10.013