Fertility loss: negative effects of environmental toxicants on oogenesis
نویسندگان
چکیده
There has been a global decline in fertility rates, with ovulatory disorders emerging as the leading cause, contributing to lifetime infertility prevalence of 17.5%. Formation primordial follicle pool during early and further development oocytes after puberty is crucial determining female reproductive quality. However, increasing exposure environmental toxins (through occupational ubiquitous chemicals) daily life growing concern; these have identified significant risk factors for oogenesis women. In light this concern, review aims enhance our understanding system diseases their implications. Specifically, we summarized categorized that can affect oogenesis. Here, provide an overview oogenesis, highlighting specific stages may be susceptible influence toxins. Furthermore, discuss genetic molecular mechanisms by which various toxins, including metals, cigarette smoke, agricultural industrial Raising awareness about potential risks associated toxin crucial. research needed fully comprehend underlying effects, identification biomarkers assess levels predict outcomes. By providing comprehensive overview, contribute better impact on guide future field.
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2023
ISSN: ['1664-042X']
DOI: https://doi.org/10.3389/fphys.2023.1219045