Feeling unreal: a functional imaging study in patients with Kleine-Levin syndrome

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Feeling unreal: a functional imaging study in patients with Kleine-Levin syndrome.

Kleine-Levin syndrome is characterized by relapsing-remitting episodes of severe hypersomnia, cognitive impairment, apathy, derealization and behavioural disturbances. Between episodes, patients have normal sleep, mood and behaviour. Functional imaging studies performed in small series of patients with Kleine-Levin syndrome with visual or semi-quantitative, uncontrolled analysis yielded equivoc...

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Kleine-Levin syndrome: a systematic study of 108 patients.

OBJECTIVE Kleine-Levin syndrome is a rare disorder characterized by relapsing-remitting episodes of hypersomnia, cognitive disturbances, and behavioral disturbances, such as hyperphagia and hypersexuality. METHODS We collected detailed clinical data and blood samples on 108 patients, 79 parent pairs, and 108 matched control subjects. We measured biological markers and typed human leukocyte an...

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Kleine-Levin syndrome: a review

Kleine-Levin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. This article reviews the current available research and describes common clinical symptoms, differential diagnosis, and acceptable workup and treatment. Although deficits have traditionally been thought to resolve between episodes, functional imaging studies and lo...

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Kleine–Levin Syndrome: A case report☆

Kleine-Levin Syndrome is an unusual sleep disorder occurring predominantly, but not exclusively, in late adolescent males. A case is described which illustrates some of the difficulties in diagnosis and management.

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A case of Kleine-Levin syndrome.

The positive correlation seen in the ER, PR scores and Her 2 neu amplification between the primary tumour and lymph node metastases and the absence of a significant difference between the score of ER, PR and the amplification of Her 2 neu between the primary tumour and the lymph node metastases indicates that there is a concordance in these parameters between the primary tumour and its nodal me...

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ژورنال

عنوان ژورنال: Brain

سال: 2014

ISSN: 1460-2156,0006-8950

DOI: 10.1093/brain/awu112