منابع مشابه
Simplified (13)C metabolic modeling for simplified measurements of cerebral TCA cycle rate in vivo.
(13)C NMR spectroscopy is a unique tool to measure the cerebral tricarboxylic acid (TCA) cycle rate in vivo. The measurement relies on metabolic modeling of glutamate C3 and C4 enrichment time courses during a (13)C-glucose intravenous infusion. Usual metabolic models require the plasma glucose and (13)C-glucose time courses as input functions, as well as the knowledge of Michaelis-Menten kinet...
متن کاملGATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle
The GATOR1 (SEACIT) complex consisting of Iml1-Npr2-Npr3 inhibits target of rapamycin complex 1 (TORC1) in response to amino acid insufficiency. In glucose medium, Saccharomyces cerevisiae mutants lacking the function of this complex grow poorly in the absence of amino acid supplementation, despite showing hallmarks of increased TORC1 signaling. Such mutants sense that they are amino acid reple...
متن کاملTemporal fluxomics reveals oscillations in TCA cycle flux throughout the mammalian cell cycle
Cellular metabolic demands change throughout the cell cycle. Nevertheless, a characterization of how metabolic fluxes adapt to the changing demands throughout the cell cycle is lacking. Here, we developed a temporal-fluxomics approach to derive a comprehensive and quantitative view of alterations in metabolic fluxes throughout the mammalian cell cycle. This is achieved by combining pulse-chase ...
متن کاملNMR study of gluconeogenesis and TCA cycle flux in humans
JOHN G. JONES,1 MICHAEL A. SOLOMON,2 SUZANNE M. COLE,3 A. DEAN SHERRY,1,3 AND CRAIG R. MALLOY1,2 1Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235; 2Department of Internal Medicine, University of Texas Southwestern Medical Center and Department of Veterans Affairs Medical Center, Dallas 75216; and 3Department of Chemistry, University of Dallas, Richardson, ...
متن کاملMitochondrial metabolism in TCA cycle mutant cancer cells
Normal cells and cancer cells rely on mitochondria for a range of essential functions including production of ATP, biosynthetic intermediates, heme and ironsulfur clusters, and reactive oxygen species (ROS) for signaling. These functions are essential for cell survival and proliferation. Most cancer cells have functional mitochondria to fulfill these essential requirements; however, there is a ...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2016
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc.2016.29