FcγRIIb expression in early stage chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
Risk-Adapted Therapy in Early-Stage Chronic Lymphocytic Leukemia.
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults and usually affects the elderly patient. More than 50% of CLL cases are diagnosed at an early disease stage, often as an incidental lymphocytosis found in a routine blood screen. For about 40 years, the classifications according to Binet or Rai have been the hands-on staging systems to stratify patients in daily clinical p...
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The biologic mechanisms involved in the clinical progression from early stages of patients with chronic lymphocytic leukemia (CLL) are not well known. We investigated sequential samples from 16 untreated CLL patients obtained at diagnosis in early stage and after progression before treatment. One patient had a p16 (INK4a) homozygous deletion at diagnosis and progression, and 3 patients acquired...
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| 1422 | haematologica | 2008; 93(9) ment options. We observed that those of our patients treated with rituximab-based regimens who were assigned to the high risk group had a median overall and cause-specific survival of less than four years. When such patients were treated with alkylating agents or with nucleoside analogs median overall survival was also less than four years. This observation ...
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Identification of prognosticators for Binet A chronic lymphocytic leukemia is important for selecting patients with dismal prognosis. We analyzed CD49d expression in 140 consecutive Binet A chronic lymphocytic leukemia. At diagnosis, CD49d >or=30% (54/140, 38.6%) associated with proliferation markers, namely CD38 >or=30% (p=3.9 x 10(-6)), LDH (p=0.007) and beta2-microglobulin (p=0.020). Univari...
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Background and Aims: Chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Research has shown that in CLL, microRNAs can have function as oncogenes or tumor suppressors. Some studies demonstrated that the expression of microRNA-93 (miR-93) and microRNA-330 (miR-330) have been changed in several can...
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ژورنال
عنوان ژورنال: Leukemia & Lymphoma
سال: 2017
ISSN: 1042-8194,1029-2403
DOI: 10.1080/10428194.2017.1307981