منابع مشابه
Biology of human immunoglobulin G Fc receptors.
A heterogeneous group of receptors binding the Fc region of Ig, Fc receptors, provides important links between the cellular and humoral branches ofthe immune system. The members of this receptor group, specific for essentially all the Ig isotypes, are expressed on a variety of cells and mediate multiple important functions. Receptors for IgG (Fc’yR) , a subgroup within the larger group of FcR, ...
متن کاملEpidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI
Human epidermal Langerhans cells (LC) bearing IgE are found in disease states associated with hyperimmunoglobulinemia E. When studying the mechanism(s) underlying this phenomenon, immunohistology revealed that a majority of epidermal LC from normal skin of healthy individuals can specifically bind monomeric IgE. IgE binding to LC could neither be prevented by preincubation of the tissue with mo...
متن کاملHuman epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI)
It has been suggested that epidermal Langerhans cells (LC) bearing immunoglobulin E (IgE) may be involved in the genesis of atopic disease. The identity of the IgE receptor(s) on LC remained unclear, although it represents a crucial point in understanding cellular events linked to the binding of allergens to LC via IgE. In this report, we demonstrate that epidermal LC express the high affinity ...
متن کاملLangerhans Cells in Skin Lesions of Leprosy
Background: Langerhans cells are important in the pathogenesis of leprosy. A recent study reported that these cells were almost absent in the epidermis overlying lepromatous lesions. Objective: To investigate a possible relationship between the number of Langerhans cells and the histopathologic spectrum of lesions in patients with leprosy. Methods: An immunohistochemical staining for S100 prot...
متن کاملInduction of Fc epsilon R2/CD23 on human epidermal Langerhans cells by human recombinant interleukin 4 and gamma interferon
Human rIL-4 and human rIFN-gamma are able to induce the expression of the low affinity receptor for IgE (Fc epsilon R2/CD23) on normal human epidermal Langerhans cells, whereas IL-2 and PMA have no effect. A synergistic effect is observed when both cytokines are combined. These receptors are synthesized de novo by the LC since cycloheximide completely inhibits the appearance of Fc epsilon R2/CD...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1990
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12874984