منابع مشابه
Fcγ Receptor Heterogeneity in Leukocyte Functional Responses
Antibodies participate in defense of the organism from all types of pathogens, including viruses, bacteria, fungi, and protozoa. IgG antibodies recognize their associated antigen via their two Fab portions and are in turn recognized though their Fc portion by specific Fcγ receptors (FcγRs) on the membrane of immune cells. Multiple types and polymorphic variants of FcγR exist. These receptors ar...
متن کاملFcγ receptor IIb strongly regulates Fcγ receptor-facilitated T cell activation by dendritic cells.
FcγR ligation by Ag-Ab immune complexes (IC) not only mediates effective Ag uptake, but also strongly initiates dendritic cell (DC) maturation, a requirement for effective T cell activation. Besides the activating FcγRI, FcγRIII, and FcγRIV, the inhibitory FcγRIIb is expressed on DCs. It is unclear how the ratio between signals from the activating FcγR and the inhibitory FcγRIIb determines the ...
متن کاملImmunotherapy targeting inhibitory Fcγ receptor IIB (CD32b) in the mouse is limited by monoclonal antibody consumption and receptor internalization.
Genetic deficiency of the inhibitory Fc receptor, FcγRIIB (CD32b), has been shown to augment the activity of activatory FcγR and promote mAb immunotherapy. To investigate whether mAbs capable of blocking FcγRIIB have similar capacity, we recently generated a panel of specific anti-mouse FcγRIIB mAbs that do not cross-react with other FcRs, allowing us to study the potential of FcγRIIB as a ther...
متن کاملFcγ Receptor-Mediated Inflammation Inhibits Axon Regeneration
Anti-glycan/ganglioside antibodies are the most common immune effectors found in patients with Guillain-Barré Syndrome, which is a peripheral autoimmune neuropathy. We previously reported that disease-relevant anti-glycan autoantibodies inhibited axon regeneration, which echo the clinical association of these antibodies and poor recovery in Guillain-Barré Syndrome. However, the specific molecul...
متن کامل[Fcγ receptor and systemic autoimmune disease].
The systemic autoimmune disease such as systemic lupus erythematosus (SLE) is characterized by the deposition of immune complexes in multiple organs. Fcγ receptors (FcγR) recognize the Fc portion of IgG and are important in determining the response of leukocytes to deposited immune complexes. FcγR also provide positive and negative regulation of immune cell responses. The activatory FcγR includ...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2012
ISSN: 1478-6354
DOI: 10.1186/ar3572