Fatal case of cephalexin-induced toxic epidermal necrolysis
نویسندگان
چکیده
منابع مشابه
Fatal case of cephalexin-induced toxic epidermal necrolysis
PURPOSE To describe a case of toxic epidermal necrolysis likely caused by cephalexin with a review of the literature. CASE An 80-year-old male with a known allergy to cephalosporins, residing at a long-term acute care hospital, received cephalexin for a urinary tract infection. And 1 day after starting therapy, the patient developed an extensive erythematous rash accompanied by skin sloughing...
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Toxic Epidermal Necrolysis (TEN) which is characterized by the detachment of the epidermis from the dermis is a rare (1.89/1.000.000 annually) and potentially life-threatening condition. The overall mortality is 20 - 30%. TEN is characterized by sudden apoptosis of keratinocytes leading to mucous membrane erosions and epidermal detachment; detachment of less than 10% of the total body surface a...
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We present a case of phenytoin-induced toxic epidermal necrolysis resulting in 60-70% skin involvement. Systemic corticosteroids and prophylactic antibiotics used initially were discontinued, and subsequent management concentrated on intensive supportive treatment. The patient survived, but is left with disabling ocular complications.
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ژورنال
عنوان ژورنال: SAGE Open Medical Case Reports
سال: 2014
ISSN: 2050-313X,2050-313X
DOI: 10.1177/2050313x14532250