Fatal anaphylactoid reaction after primary exposure to aprotinin

Fatal anaphylactoid reaction after primary exposure to aprotinin.

Aprotinin is widely used to prevent bleeding, inhibit systemic inflammatory response and reduce blood transfusions after cardiac surgery. Because it is a bovine protein, aprotinin can induce hypersensitivity reactions. We report a case of fatal anaphylactoid reaction to primary aprotinin exposure in a woman who was admitted for mitral valve replacement. The possibility of anaphylactic reaction ...

Anaphylactoid reaction to carboplatin: successful "desensitization".

Carboplatin (CP) hypersensitivity reactions have been reported in nearly 12 % of patients treated with this drug. The pathophysiologic mechanisms of these reactions have not been entirely elucidated. Various hypotheses are under discussion. CP hypersensitivity reactions could be IgE-mediated, caused by low-molecular platinum compounds acting as haptens. Platinum salts are also able to release h...

Fatal reaction to acetazolamide.

ACETAZOLAMIDE is known to produce many minor side-effects when given for any length of time. Becker and Middleton (1955) have described the following in seventy patients receiving long-term acetazolamide for glaucoma: paresthesiae 61 per cent., gastrointestinal disturbances 49 per cent., excessive fatigue 16 per cent., urinary disturbances 4 per cent., hearing loss 3 per cent., leucopenia 3 per...

Phototoxic Reaction after Exposure to Bitumen

Lindberg SW1*, Agner T2 and Pedersen EB1 1Department of Occupational and Environmental Medicine, University of Copenhagen, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark 2Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark *Corresponding author: Sara Lindberg, Department of Occupational and Environmental Medicine, Bispebjerg Hospital, Denmark,...

Reaction after re-exposure to trimethoprim-sulfamethoxazole.