Fast 3 T nigral hyperintensity magnetic resonance imaging in Parkinson’s disease
نویسندگان
چکیده
Abstract The absence of nigral hyperintensity is a promising MR marker for Parkinson’s disease (PD), but its small size imposes limitations on routine use. Our aim was to compare Multi Echo Data Image Combination (MEDIC), segmented echo-planar imaging (EPISEG) and fluid-attenuated inversion recovery (FLAIR) sequences, as well both magnitude (MAG) susceptibility-weighted (SWI) reconstructions single-echo gradient echo imaging. Twenty-five healthy twenty PD subjects were included. Sensitivity motion artefacts, confidence the radiologist in interpretation, rate nondiagnostic scans diagnostic accuracy assessed. EPISEG less motion-sensitive than MEDIC, MAG, SWI, while FLAIR MAG SWI. reviewers more confident when using compared any other techniques MEDIC superior FLAIR. proportions lower sequences. best performance achieved (sensitivity = 65%, specificity 96%). Using EPISEG, associated with higher Hoehn-Yahr stage MDS-UPDRS II + III. Nigral may be intact at very early stages PD. properties help transfer into daily clinical practice.
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: ['2045-2322']
DOI: https://doi.org/10.1038/s41598-020-80836-7