Fasciola hepatica: Histological demonstration of apoptosis in the reproductive organs of flukes of triclabendazole-sensitive and triclabendazole-resistant isolates, and in field-derived flukes from triclabendazole-treated hosts, using in situ hybridisation to visualise endonuclease-generated DNA strand breaks
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Fasciola hepatica: Histology of the Reproductive Organs and Differential Effects of Triclabendazole on Drug-Sensitive and Drug-Resistant Fluke Isolates and on Flukes from Selected Field Cases
This review summarises the findings of a series of studies in which the histological changes, induced in the reproductive system of Fasciola hepatica following treatment of the ovine host with the anthelmintic triclabendazole (TCBZ), were examined. A detailed description of the normal macroscopic arrangement and histological features of the testes, ovary, vitelline tissue, Mehlis' gland and ute...
متن کاملA joint AFBI / DAFM Veterinary Laboratories publication
79high (case) or low (control) calf mortality wererecruited . A herd-level questionnaire was usedto gather information on management practiceslikely to impact bovine perinatal mortality . Thequestionnaire was divided into four subsectionsdealing with pre-calving (breeding, diet and bodycondition score, endemic infectious diseases) andcalving factors . Most of the...
متن کاملAn amino acid substitution in Fasciola hepatica P-glycoprotein from triclabendazole-resistant and triclabendazole-susceptible populations.
Control of fasciolosis is threatened by the development of anthelmintic resistance. Enhanced triclabendazole (TCBZ) efflux by ABC transporters such as P-glycoprotein (Pgp) has been implicated in this process. A putative full length cDNA coding for a Pgp expressed in adult Fasciola hepatica has been constructed and used to design a primer set capable of amplifying a region encoding part of the s...
متن کاملLack of reversion in triclabendazole-resistant Fasciola hepatica.
RESISTANCE to triclabendazole in field isolates of the liver fluke Fasciola hepatica in sheep was described for the first time by Overend and Bowen (1995) in Australia. In Europe, resistance of F hepatica in sheep to triclabendazole has been reported in Ireland (Lane 1998), Scotland (Mitchell and others 1998), Wales (Thomas and others 2000) and the Netherlands (Moll and others 2000). On the Dut...
متن کاملUnchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes
BACKGROUND The reduced drug accumulation based on enhanced drug efflux and metabolic capacity, identified in triclabendazole (TCBZ)-resistant Fasciola hepatica may contribute to the development of resistance to TCBZ. The aim of this work was to evaluate the pharmacokinetics and clinical efficacy of TCBZ administered alone or co-administered with ivermectin (IVM, efflux modulator) and methimazol...
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ژورنال
عنوان ژورنال: Veterinary Parasitology
سال: 2013
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2012.09.014