Family history versus SNPs for disease predictions
نویسندگان
چکیده
منابع مشابه
Comparison of Family History and SNPs for Predicting Risk of Complex Disease
The clinical utility of family history and genetic tests is generally well understood for simple Mendelian disorders and rare subforms of complex diseases that are directly attributable to highly penetrant genetic variants. However, little is presently known regarding the performance of these methods in situations where disease susceptibility depends on the cumulative contribution of multiple g...
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There are many well-established factors that influence the risk of stroke including blood pressure, diabetes, low socioeconomic status and smoking, however, the shared genetic resource in members of a family effect on stroke predisposition. Genome-wide association studies (GWAS) have demonstrated evidence of a shared genetic source in stroke risk. This review considered the influence of family...
متن کاملFamily history of cardiovascular disease.
Evidence Where possible, odds ratios (ORs) have been converted to relative risks (RRs). • A total of 2302 male and female Framingham offspring study participants with parental history of premature CVD (father < 55 years, mother < 65 years) were analyzed for CVD risk.1 After 8 years of followup, CVD increased 75% with paternal and about 60% with maternal history of premature CVD. • Using the sam...
متن کاملHeart disease, family history and physical activity.
OBJECTIVES This article examines the association of family history of heart disease and leisure-time physical activity with incident heart disease. DATA SOURCE The data are from the 1994/95, 1996/97 and 1998/99 longitudinal household components of Statistics Canada's National Population Health Survey. This study is based on information provided by 9,255 respondents aged 20 or older who report...
متن کاملBrief screening for family psychiatric history: the family history screen.
BACKGROUND Brief screens to collect lifetime family psychiatric history are useful in clinical practice and for identifying potential families for genetic studies. METHODS The Family History Screen (FHS) collects information on 15 psychiatric disorders and suicidal behavior in informants and their first-degree relatives. Since each question is posed only once about all family members as a gro...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2012
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3385