Familial Predisposition for Psychiatric Disorder

Familial predisposition for psychiatric disorder: comparison of subjects treated for cannabis-induced psychosis and schizophrenia.

CONTEXT Cannabis-induced psychosis is considered a distinct clinical entity in the existing psychiatric diagnostic systems. However, the validity of the diagnosis is uncertain. OBJECTIVES To establish rate ratios of developing cannabis-induced psychosis associated with predisposition to psychosis and other psychiatric disorders in a first-degree relative and to compare them with the correspon...

Genetic Basis of Familial Lymphoma Predisposition

Mitochondria and Familial Predisposition to Breast Cancer

Mitochondrial genome and functional alterations are related to various diseases including cancer. In all cases, the role of these organelles is associated with defects in oxidative energy metabolism and control of tumor-induced oxidative stress. The present study examines the involvement of mitochondrial DNA in cancer and in particular in breast cancer. Furthermore, since mitochondrial DNA is m...

Familial predisposition and genetic risk factors for lymphoma.

Our understanding of familial predisposition to lymphoma (collectively defined as non-Hodgkin lymphoma [NHL], Hodgkin lymphoma [HL], and chronic lymphocytic leukemia [CLL]) outside of rare hereditary syndromes has progressed rapidly during the last decade. First-degree relatives of NHL, HL, and CLL patients have an ∼1.7-fold, 3.1-fold, and 8.5-fold elevated risk of developing NHL, HL, and CLL, ...

Familial Predisposition for Salivary Gland Cancer in Finland

BACKGROUND Salivary gland cancer (SGC) accounts for 3-5% of head and neck malignancies, and register-based studies estimate the familial proportion to be 0.15%. OBJECTIVE We studied familial predisposition for SGC in the genetically distinct Finnish population. PATIENTS AND METHODS We sent a patient questionnaire to 161 Finnish SGC patients, 86 of whom responded. RESULTS A total of 76% of...