Familial Neonatal Neutropenia with Maternal Leukocyte Antibodies

Familial Neonatal Neutropenia with Maternal Leukocyte Antibodies

I SOIMMUNE leukocyte antibodies have been reported frequently since the initial communication of Dausset and Nenna’ in 1952. A large literature has accumulated and was recently fully reviewed by Walford,2 who listed over 500 reports. Most of these have been concerned chiefly with establishing the presence of such antibodies, the mechanisms by which they cause pathological effects being still co...

Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia.

The healthy mother of a child with transient immune neutropenia was found to be "NA-null." The mother's neutrophils did not react with anti-NA1 and anti-NA2 antibodies (polyclonal human alloantibodies and mouse monoclonal antibodies). A healthy donor was discovered during routine neutrophil antigen typing whose neutrophils were also "NA-null." This NA-phenotype was due to the absence of FcRIII ...

Neonatal neutropenia due to maternal autoantibodies against neutrophils.

Granulocyte Antibodies in Korean Neonates with Neutropenia

Neonatal alloimmune neutropenia (NAN) is a disease that can cause severe and prolonged neutropenia in neonates. However, no report is available on the incidence of granulocyte antibody in neonates, the target antigen of this antibody, and the estimated incidence of NAN in Korea. Among a total of 856 neonates admitted to a neonatal intensive care unit (NICU) over a five year period, a total of 1...

Neonatal Jaundice Associated with Familial

It is now well established that hyperbilirubinaemia and even kernikterus may occur in the newborn in association with glucose 6 phosphate dehydrogenase (G6PD) deficiency, in the absence of any of the other causes of neonatal jaundice (Panizon, 1960a, b; Doxiadis, Fessas, and Valaes, 1960; Doxiadis, Fessas, Valaes, and Mastrokalos, 1961; Fessas, Doxiadis, and Valaes, 1962; Smith and Vella, 1960;...