Familial Clustering of Hodgkin Lymphoma and Multiple Sclerosis
نویسندگان
چکیده
منابع مشابه
Familial clustering of Hodgkin lymphoma and multiple sclerosis.
BACKGROUND Epidemiologic similarities between Hodgkin lymphoma in young adults (i.e., between 15 and 44 years old) and multiple sclerosis have led to the suggestion that these diseases may have related etiologies. Previous investigations have not supported this hypothesis, but the negative results could have been caused by methodologic problems. We therefore assessed the risk of developing Hodg...
متن کاملRe: Familial clustering of Hodgkin lymphoma and multiple sclerosis.
We were intrigued by the recent report of Hjalgrim et al. (1) that showed familial clustering of multiple sclerosis and young-adult-onset Hodgkin lym-phoma in Denmark and that supported Newell ' s 1970 hypothesis (2) of a shared etiology. Their study and another report by Vineis et al. (3) indicate a familial association between multiple sclerosis and non-Hodgkin lymphoma. Given the etiologic i...
متن کاملHodgkin Lymphoma and Anaplastic Variants of Non-Hodgkin Lymphoma
Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. Materials and Methods:...
متن کاملMultiple sclerosis and risk of young-adult-onset Hodgkin lymphoma.
OBJECTIVE To determine whether there is an association between multiple sclerosis (MS) and young-adult-onset Hodgkin lymphoma (YAHL) as this will signal etiologic similarities relevant both to inherited characteristics and environmental exposures in childhood. METHODS Swedish general population registers identified a cohort of 29,617 with an MS diagnosis between 1968 and 2012, matched with a ...
متن کاملMeta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis
BACKGROUND Based on epidemiological commonalities, multiple sclerosis (MS) and Hodgkin lymphoma (HL), two clinically distinct conditions, have long been suspected to be aetiologically related. MS and HL occur in roughly the same age groups, both are associated with Epstein-Barr virus infection and ultraviolet (UV) light exposure, and they cluster mutually in families (though not in individuals)...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2004
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djh135