FAL1 ing inside an Amplicon

Tubulogenesis: An Inside Job

Size does matter. While endlessly debated in social circles, this is unquestionably true for the normal function of the epithelial and endothelial tubes that comprise such organs as the vascular system, lung and kidney. The enlarged tubules in a polycystic kidney, for instance, literally crush the surrounding normal tubules, while narrowed blood vessels can cause ischemic tissue injuries. Surpr...

Oncogenic long noncoding RNA FAL1 in human cancer

Long non-coding RNAs (lncRNAs) are defined as RNA transcripts larger than 200 nucleotides that do not appear to have protein-coding potential. Accumulating evidence indicates that lncRNAs are involved in tumorigenesis. Our work reveals that lncRNA FAL1 (focally amplified lncRNA on chromosome 1) is frequently and focally amplified in human cancers and mediates oncogenic functions.

An inside job.

Protosolid: An inside look

PROTOSOLID is a solid modeler that represents solids with planar surfaces and manipulates the solids with regularized set operations. This paper looks at the internal structures and operations of PROTOSOLID and is intended as a programmer user guide. A boundary of a solid is represented by a/edge-based data structure. It is developed in ComrnonLisp. IThill work hILS been supported in part by an...

Retinoblastoma, an Inside Job

Why are some cell types more prone to transformation than others? In this issue, Xu et al. (2009) show that retinoblastoma cells co-opt several intrinsic features of cone photoreceptors for their survival and growth.