Failure of Fondaparinux in Autoimmune Heparin-Induced Thrombocytopenia
نویسندگان
چکیده
منابع مشابه
Fondaparinux-associated heparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia (HIT) is an immune-mediated clinical syndrome of thrombocytopenia and thrombosis occurring after exposure to heparin. HIT most commonly occurs after exposure to unfractionated heparin but has also been reported with low-molecular-weight heparin. To date, there have been very few reports of HIT with the pentasaccharide fondaparinux, and some have proposed fondapa...
متن کاملThe Fondaparinux Paradox: Fondaparinux-Related Heparin-induced Thrombocytopenia
Fondaparinux, a pentasaccharide administered for heparin-induced thrombocytopenia (HIT), can lead to the occurrence of thrombocytopenia. This patient underwent aortic stent graft placement for Salmonella paratyphi A-infected abdominal aortic aneurysm. Fondaparinux was administered for anticoagulation that led to a dramatic decline in his platelet counts. Investigations revealed HIT profile, PF4...
متن کاملHeparin-induced thrombocytopenia in a patient treated with fondaparinux.
A 45-year-old female presented with complaints of left leg cramps lasting 2 weeks and 1 day of leg swelling. Doppler ultrasound revealed left lower extremity deep vein thrombosis (DVT), which was thought to be secondary to trauma. The patient had a history of ampullary cancer that had metastasized to the liver, for which she underwent a Whipple procedure, radiotherapy, and chemotherapy. Additio...
متن کاملHeparin induced thrombocytopenia
Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...
متن کاملFondaparinux for thromboembolic treatment and prophylaxis of heparin-induced thrombocytopenia.
OBJECTIVE To review literature evaluating the use of fondaparinux for thromboembolic treatment and prophylaxis in patients with heparin-induced thrombocytopenia (HIT). DATA SOURCES A MEDLINE search (1966-February 2006) was conducted using the search terms fondaparinux, heparin, low-molecular-weight heparin, and thrombocytopenia to identify English-language articles. Additional sources were id...
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ژورنال
عنوان ژورنال: TH Open
سال: 2020
ISSN: 2512-9465
DOI: 10.1055/s-0040-1713175