Factors contributing to decreased protein stability when aspartic acid residues are in β-sheet regions
نویسندگان
چکیده
منابع مشابه
The distribution of aspartic acid residues in bovine dentine phosphoprotein.
Recently, Weiner and Hood (Science 190:987989, 1975) reported the use of an acid hydrolysis procedure in the study of the aspartic acid linkages of the soluble protein of the organic matrix of mollusk shells. Peptide bonds on both sides of aspartic acid residues have been shown to be particularly labile to hydrolysis by dilute acetic or hydrochloric acids (SCHULTZ et al, Biochemistry 1:694-698,...
متن کاملTryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation.
Myeloperoxidase, released by activated phagocytes, forms reactive oxidants by catalysing the reaction of halide and pseudo-halide ions with H(2)O(2). These oxidants have been linked to tissue damage in a range of inflammatory diseases. With physiological levels of halide and pseudo-halide ions, similar amounts of HOCl (hypochlorous acid) and HOSCN (hypothiocyanous acid) are produced by myeloper...
متن کاملNew Charge-Bearing Amino Acid Residues That Promote β-Sheet Secondary Structure
Proteinogenic amino acid residues that promote β-sheet secondary structure are hydrophobic (e.g., Ile or Val) or only moderately polar (e.g., Thr). The design of peptides intended to display β-sheet secondary structure in water typically requires one set of residues to ensure conformational stability and an orthogonal set, with charged side chains, to ensure aqueous solubility and discourage se...
متن کاملFactors Contributing to Motivation among Iranian EFL In-Service Teachers
Since learning English as a foreign language in Iran has turned into one of the mostimportant issues in educational settings, especially in recent years, having motivated teachersin education and maintaining this motivation is one of the defining factors in assuring students’learning. Teachers' motivation affects the process of teaching and EFL learners’ achievement.The present study was an att...
متن کاملAge-dependent accumulation of protein residues which can be hydrolyzed to D-aspartic acid in human erythrocytes.
We have measured the rate of accumulation of amino acid residues in human erythrocyte membrane and cytosolic proteins which give D-aspartic acid upon acid hydrolysis. These residues would include D-aspartic acid, D-asparagine, as well as the beta-transpeptidation product, D-isoaspartic acid. Measurements made using age (density) fractionated cells indicate that racemization at these residues oc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Protein Science
سال: 2009
ISSN: 0961-8368
DOI: 10.1110/ps.4920102