Factor XIII-A in Diseases: Role Beyond Blood Coagulation

Multidisciplinary research from the last few decades has revealed that Factor XIII subunit A (FXIII-A) is not only involved in blood coagulation, but may have roles various diseases. Here, we aim to summarize data studies involving patients with mutations F13A1 gene, performed FXIII-A knock-out mice models, clinical and histological assessing correlations between diseases severity levels, as well vitro experiments. By providing a complex overview on its possible role wound healing, chronic inflammatory bowel diseases, athe-rosclerosis, rheumatoid arthritis, lung rhinosinusitis, solid tumors, hematological malignancies, obesity, also demonstrate how field evolved using marker accept understand active malignant