منابع مشابه
Factor V Leiden prevalence in venous thromboembolism patients.
BACKGROUND Recent findings have demonstrated a high frequency of activated protein C resistance in patients suffering from deep venous thrombosis (DVT). This abnormality has been related to a mutation in the factor V gene (at nucleotide position 1,691, guanine to adenine [G-->A] substitution). AIM To assess the frequency of the mutation in unselected inpatients with a proved DVT. To study the...
متن کاملFactor V Leiden and factor V R2 allele: high-throughput analysis and association with venous thromboembolism.
Thrombophilia is a multigenic disease in which the combination of genetic polymorphisms increases the risk of deep vein thrombosis (DVT). The rapid identification of these genetic combinations requires high-throughput analysis of single nucleotide polymorphisms (SNPs). The TaqMan fluorogenic 5'-->*3' nuclease assay (PE/Applied Biosystems, Foster City, CA) with custom-designed primers, probes an...
متن کاملThe association of factor V Leiden with various clinical patterns of venous thromboembolism-the factor V Leiden paradox.
BACKGROUND Factor V Leiden (FVL) supposedly carries relatively higher risk of deep vein thrombosis (DVT), compared to the risk of pulmonary embolism (PE). AIM To prove this paradox in a group of patients with various clinical presentation of venous thromboembolism (VTE). MATERIALS AND METHODS We retrospectively evaluated clinical pattern of VTE in patients who had been referred to vascular ...
متن کاملFrequency of Factor II G20210A and Factor V Leiden Mutations in Algerian Patients with Venous Thromboembolism
Several inherited polymorphisms are associated with the risk of venous thrombosis, including mutation at codon 506 of the factor V gene and mutation at position 20210 of the prothrombin gene. The aim of this study was to determine the frequency of factor II G20210A and factor V Leiden mutations in Algerian patients with venous thromboembolism disease. In this study, genotyping for factor V Leid...
متن کاملFactor V Leiden and Inflammation
Factor V Leiden, is a variant of human factor V (FV), also known as proaccelerin, which leads to a hypercoagulable state. Along these years, factor V Leiden (FVL) has been studied from the pathophysiologic point of view, and research has been focused on finding clinical approaches for the management of the FVL associated to a trombophilic state. Less attention has been paid about the possible r...
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ژورنال
عنوان ژورنال: Basrah Journal of Surgery
سال: 2004
ISSN: 2409-501X
DOI: 10.33762/bsurg.2004.57529