Facile, novel two-step syntheses of benzimidazoles, bis-benzimidazoles, and bis-benzimidazole-dihydroquinoxalines
نویسندگان
چکیده
منابع مشابه
The synthesis of dicationic extended bis-benzimidazoles.
The synthesis of extended dicationic bis-benzimidazoles starting from trans-1,2-bis(4-cyanophenyl)ethene and trans-1,2-bis(4-cyanophenyl)cyclopropane is reported. The target diamidines show significant in vitro activity against B. subtilis.
متن کاملThe Influence of Substituents on the Tautomerism of Symmetrically Substituted 2,2’-Bis- benzimidazoles
O tautomerismo de cinco 2,2'-bis-benzimidazóis, simetricamente substituídos, [5(6),5’(6’)tetrametil(1); 5(6),5’(6’)-dimetil-(2); 5(6),5’(6’)-dicloro(3); 5(6),5’(6’)-dimetoxi(4) e 4(7),4’(7’)dimetil-2,2’-bis-benzimidazol (5)], foi estudado por espectroscopia de H RMN, a várias temperaturas, e a influência dos substituintes nas barreiras energéticas de interconversão tautomérica, interpretada atr...
متن کاملEvaluation of bis-benzimidazoles in the treatment of murine lymphocytic choriomeningitis virus infections.
Seventy percent of the mice receiving (S,S)-1,2-bis(5-methoxy-2-benzimidazolyl)-1,2-ethandiol (A36683) in their drinking water lived at least four times longer than control mice when infected with 10 or 100 mean lethal doses of lymphocytic choriomeningitis virus strain UBC. In the next 4 months, most of the survivors died with lymphocytic choriomeningitis-like symptoms. Drug treatment during th...
متن کاملParallel synthesis of 2-sulphanylated bis-benzimidazoles on soluble polymer support.
A well-sustained multistep synthetic protocol has been designed for the PEG-functionalized aromatic acid amide to generate a molecular library of 2-alkylthio bis-benzimidazoles. An attempted synthesis of benzimidazole-2-thiol in dichloromethane has led to S-chloromethyl methyl sulfides, mimicking bacterial enzymatic systems. Regioselective S-alkylation was brought about under controlled conditi...
متن کاملSequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition.
The binding of two symmetric bis-benzimidazole compounds, 2,2-bis-[4'-(3"-dimethylamino-1"-propyloxy)phenyl]-5,5-bi-1H-benzimidazole and its piperidinpropylphenyl analog, to the minor groove of DNA, have been studied by DNA footprinting, surface plasmon resonance (SPR) methods and molecular dynamics simulations in explicit solvent. The footprinting and SPR methods find that the former compound ...
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ژورنال
عنوان ژورنال: Molecular Diversity
سال: 2012
ISSN: 1381-1991,1573-501X
DOI: 10.1007/s11030-011-9354-x