Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments

In pharmaceutical development, more and drugs are classified as poorly water-soluble or insoluble. Particle size reduction is a common way to fight this trend by improving dissolution rate, transport characteristics bioavailability. Pulsed laser ablation ground-breaking technique of drug particle generation in the nano- micrometer range. Meloxicam, commonly used nonsteroidal anti-inflammatory with poor water solubility, was chosen model drug. The pastille pressed meloxicam targets were irradiated Ti:sapphire (? = 135 fs, ?c 800 nm) air distilled water. Fourier transform infrared Raman spectroscopies for chemical characterization scanning electron microscopy determine morphology size. Additional studies performed using mobility sizer. Our experiments demonstrated that significant can be achieved both without any change meloxicam. ablated particles (~50 nm few microns) approximately at least one-tenth (~10–50 micron) commercially available crystals. Furthermore, nanoaggregate formation described during pulsed air, which scarcely studied drug/organic molecules before.