Fabrication of Nanowalled Catalytically Self-Threaded Supramolecular Polyrotaxane Microcapsules Using Droplet Microfluidics

Micrometer-scale monodisperse droplets are produced to generate nanowalled supramolecular microcapsules using microfluidics for high reproducibility and high-throughput manipulation, efficient material consumption, control over hierarchical structure, shape, size. In this study, an optimized microfluidic droplet generation technique a unique liquid–liquid interfacial polymerization method were applied fabricate the polyrotaxane–based in fast simple way. To minimize uncertainty due volume variation, inlet pressures supplied from same source while lowering tension main channel hydrodynamic resistance, which critical monodispersity. The target polyrotaxane network (PN) was simply formed at interface of water oil phases ultra-monodisperse microdroplets via cucurbit[6]uril (CB6)-catalyzed azide–alkyne cycloaddition (CB6-AAC) reaction between azido- alkyne-functionalized tetraphenylporphyrin monomers (TPP-4AZ TPP-4AL). thickness interfacially assembled PN 20 nm as analyzed by cross-sectional TEM TEM-EDX techniques. resultant water-in-oil highly size able retain molecules. Here, rhodamine 6G (Rh6G)-loaded fabricated, release rate Rh6G cargo investigated time controlled drug applications.