Fabrication of Biologically Active Fish Bone Derived Hydroxyapatite and Montmorillonite Blended Sodium Alginate Composite for In-Vitro Drug Delivery Studies

Fishbone comprising hydroxyapatite (bio-ceramic) is regularly viewed as a natural resource for biological and pharmaceutical applications. In this study, has been prepared from fishbone waste using thermal calcination method. The composite hydroxyapatite–montmorillonite–sodium alginate was synthesized by co-precipitation Various functional groups of biocomposite were characterised Fourier transform infrared spectroscopy. Thermal stability crystallinity analysed through gravimetric analysis X-ray diffraction studies respectively. morphological surface composites studied scanning electron microscopy. designed to study the enhanced potential such antibacterial, antioxidant, antidiabetic, drug loading releasing ability. Antioxidant anti-diabetic phosphomolybdenum α-amylase inhibitory method ability compounds (Doxorubicin Curcumin) investigated UV–spectrophotometry at different pH medium (pH = 5.5, 6.8 7.4). Additionally, in-vitro kinetic carried out on determine doxorubicin curcumin.