Fabrication and Characterization of Sildenafil Citrate Loaded Transfersomes as a Carrier for Transdermal Drug Delivery

Fabrication and Characterization of Sildenafil Citrate Loaded Transfersomes as a Carrier for Transdermal Drug Delivery

The aim of this study was to enhance the transdermal delivery of Sildenafil Citrate by encapsulation in nano sized ultra deformable vesicles, transfersomes. The thin film hydration and sonication technique was utilized in the preparation of Sildenafil Citrate loaded Transfersomes and both non ionic and ionic edge activators (anionic and cationic) were used in varying ratios to study their effec...

Transdermal Drug Delivery through Carriers: Transfersomes

Delivery of drug through Transdermal route represents a most convenient and novel approach. Transfersomes were found to be more effective as they render controlled release of drug due to depot formation in skin and were more effective in transdermal delivery. Transfersomes are applied to the skin and permeate through the stratum corneum lipid lamellar regions as a result of the hydration and os...

Transfersomes: A Novel Vesicular Carrier for Enhanced Transdermal Delivery of Sertraline: Development, Characterization, and Performance Evaluation

The aim of the present study was to investigate transfersomes as a transdermal delivery system for the poorly soluble drug, sertraline, in order to overcome the troubles associated with its oral delivery. Different transfersomal formulations were prepared with non-ionic surfactant (span 80), soya lecithin, and carbopol 940 by the rotary evaporation sonication method. The prepared formulations w...

Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles

Although sildenafil citrate (SC) is used extensively for erectile dysfunction, oral delivery of SC encounters many obstacles. Furthermore, the physicochemical characteristics of this amphoteric drug are challenging for delivery system formulation and transdermal permeation. This article concerns the assessment of the potential of nanomedicine for improving SC delivery and transdermal permeation...

Fabrication and Characterization of Maltose Microneedles for Transdermal Drug Delivery