منابع مشابه
Crosslinked alpha-elastin biomaterials: towards a processable elastin mimetic scaffold.
Elastin is a critical biochemical and biomechanical component of vascular tissue. However, elastin is also highly insoluble and therefore difficult to process into new biomaterials. We present a simple approach for synthesizing elastin-based materials from two commercially available and water-soluble components: alpha-elastin and a diepoxy crosslinker. Reaction pH was shown to modulate the degr...
متن کاملCollagen and elastin fibres.
PROCOLLAGEN-COLLAGEN CONVERSION The first extracellular step after secretion is the proteolytic cleavage of these Nand C-terminal nonhelical regions of procollagen (Bornstein, 1974). The actual location of cleavage of these extension peptides is not known, but they are probably removed during the formation of the fibre and may take part in fibrogenesis. The intermediates in the conversion of pr...
متن کاملSmad about elastin regulation.
Elastin is crucial to pulmonary function, yet it appears in the pulmonary vasculature and interstitium late in gestation in large mammals and postnatally in rodents (1). Deletion of the ELN gene in mice produces obstructive arterial disease (2, 3) and disrupts terminal airway branching as well as alveogenesis (4); moreover, several forms of elastic tissue disease collectively known as cutis lax...
متن کاملThe Composition of Elastin*
Elastin is one of the prominent fiber proteins in the body, yet one of the least well known. Very little work has been done upon its chemical and physical characterization since the early work of Richards and Gies (1) in their study of ligament, of Abderhalden and Schittenhelm (2), who accounted for 61 per cent by weight of the amino acids in elastin, and of Kossel and Kutscher (3), who studied...
متن کاملElastin in the Liver
A characteristic feature of liver cirrhosis is the accumulation of large amounts of connective tissue with the prevailing content of type I collagen. Elastin is a minor connective tissue component in normal liver but it is actively synthesized by hepatic stellate cells and portal fibroblasts in diseased liver. The accumulation of elastic fibers in later stages of liver fibrosis may contribute t...
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ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2015
ISSN: 2192-2640
DOI: 10.1002/adhm.201400781