F23. OLANZAPINE-INDUCED PERTURBATIONS OF WHOLE-BODY INSULIN SENSITIVITY MAY OCCUR VIA INACTIVATION OF CENTRAL K-ATP CHANNELS
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منابع مشابه
Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men.
Animal studies suggest that insulin action in the brain is involved in the regulation of peripheral insulin sensitivity. Whether this holds true in humans is unknown. Using intranasal application of insulin to the human brain, we studied the impacts of brain insulin action on whole-body insulin sensitivity and the mechanisms involved in this process. Insulin sensitivity was assessed by hyperins...
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Recent work has established membrane phospholipids such as phosphatidylinositol-4,5-bisphosphate (PIP(2)) as potent regulators of K(ATP) channels controlling open probability and ATP sensitivity. We here investigated the effects of phospholipids on the pharmacological properties of cardiac type K(ATP) (Kir6.2/SUR2A) channels. In excised membrane patches K(ATP) channels showed considerable varia...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2019
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbz018.435