F001 Mapkinase and regulation of sodium-proton exchanger in human red blood cell (RBC)
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چکیده
منابع مشابه
Interactions of lithium and protons with the sodium-proton exchanger of dog red blood cells
Passive movements of Li in dog red blood cells (RBC) ar like those of Na and protons in being stimulated by osmotic cell shrinkage and inhibited by amiloride. Li and protons have similar asymmetrical effects on Na-H exchange. When the intracellular fluid is made rich in Li or protons, Na-H exchange is stimulated. When the extracellular fluid is enriched in Li or protons, Na-H exchange is inhibi...
متن کاملSodium Movements in the Human Red Blood Cell
Measurements were made of the sodium outflux rate constant, (o)k(Na), and sodium influx rate constant, (i)k(Na), at varying concentrations of extracellular (Na(o)) and intracellular (Na(c)) sodium. (o)k(Na) increases with increasing [Na(o)] in the presence of extracellular potassium (K(o)) and in solutions containing ouabain. In K-free solutions which do not contain ouabain, (o)k(Na) falls as [...
متن کاملOuabain-Insensitive Sodium Movements in the Human Red Blood Cell
Red blood cells exposed to ouabain are capable of net Na outflux against an electrochemical gradient; the net outflux is inhibited by the diuretic, furosemide. In ouabain-treated cells, both the unidirectional Na outflux and the unidirectional Na influx are inhibited by furosemide. Furosemide also inhibits the ouabain-sensitive Na-Na exchange accomplished by the Na-K pump in K-free solutions. F...
متن کاملKinetic abnormalities of the red blood cell sodium-proton exchange in hypertensive patients.
The present study was designed to examine the kinetics of Na(+)-H+ exchange in red blood cells of normotensive and hypertensive subjects and its relation to the previously reported abnormalities in Na(+)-Li+ exchange. The Na(+)-H+ antiporter activation kinetics were studied by varying cell pH and measuring net Na+ influx (mmol/l cell x hr = units) driven by an outward H+ gradient. The Na(+)-Li+...
متن کاملRed blood cell sodium-proton exchange in hypertensive blacks with insulin-resistant glucose disposal.
To define the potential pathogenic role of hyperinsulinemia as a mediator of alterations in sodium transport, we have examined red blood cell Na(+)-H+ and Na(+)-Li+ exchanges in a young adult black population characterized for blood pressure and insulin-mediated glucose disposal. Normotensive and mildly hypertensive blacks (blood pressure, 120 +/- 2/76 +/- 2 and 139 +/- 3/94 +/- 2 mm Hg, respec...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1998
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(97)91276-0