Extracorporeal photochemotherapy induces bona fide immunogenic cell death
نویسندگان
چکیده
منابع مشابه
Extracorporeal Photopheresis: Tolerogenic or Immunogenic Cell Death? Beyond Current Dogma
Extracorporeal photopheresis (ECP) is an autologous cell therapy that is widely used for the treatment of T cell-mediated diseases. ECP has been FDA-approved for the treatment of cutaneous T cell lymphoma (CTCL) and has shown potent clinical benefits in various other (noncancer) T cell-mediated diseases, such as graft versus host disease (GvHD), allograft rejection, as well as in autoimmune dis...
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8-methoxypsoralen (8-MOP), activated upon exposure to long-wavelength ultraviolet radiation, is used therapeutically to treat the diseased blood cells of cutaneous T-cell lymphoma patients. The factors responsible for the efficacy of this therapy are reviewed. Primary among these are the plasma level of 8-MOP at the time of irradiation and the effective dose of UVA. 8-MOP plasma levels determin...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2019
ISSN: 2041-4889
DOI: 10.1038/s41419-019-1819-3