Extracorporeal photochemotherapy for treatment of drug-resistant graft-vs.-host disease
نویسندگان
چکیده
منابع مشابه
Extracorporeal photochemotherapy for the treatment of steroid-resistant chronic GVHD.
Chronic graft-versus-host disease (GVHD) is a major limitation of successful allogeneic hematopoietic stem cell transplantation (HSCT). Extracorporeal photochemotherapy (ECP) has been tested extensively in small cohorts of patients with chronic GVHD. In this study, we retrospectively evaluated 71 patients with severe chronic GVHD treated with ECP. Response rate was 61% (n = 43), and 14 patients...
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Chronic graft versus host disease (GVHD) remains the most common late complication of allogenic stem cell transplantation and the most frequent cause of morbidity and mortality in these patients. To control this condition, immunosuppressive drugs are usually administered at a high dose and for a long time, which may result in several side effects. 5 patients with clinically and histopathologica...
متن کاملImmunologic mechanisms of extracorporeal photochemotherapy in chronic graft-versus-host disease.
Extracorporeal photochemotherapy (ECP) has been shown to be an effective therapy for patients with acute and chronic graft-versus-host disease (GVHD) following allogeneic bone marrow transplantation, but its biologic mechanism is not understood. We reported that clinical response to ECP was associated not only with normalization of skewed CD4/CD8 ratios but also with an increase in CD3(-)/CD56(...
متن کاملSuccessful use of extracorporeal photochemotherapy in the treatment of severe acute and chronic graft-versus-host disease.
Extracorporeal exposure of peripheral blood mononuclear cells to the photosensitizing compound 8-methoxypsoralen and ultraviolet A radiation has been shown to be effective in the treatment of several T-cell-mediated diseases, including cutaneous T-cell lymphoma and rejection after organ transplantation. We present 21 patients (10 men and 11 women) with hematological malignancies with a median a...
متن کاملImmunomodulatory effects of extracorporeal photochemotherapy in patients with extensive chronic graft-versus-host disease.
Extracorporeal photochemotherapy (ECP) has been associated with clinical improvement in several patients with acute and chronic graft-versus-host disease (cGVHD) after allogeneic bone marrow transplantation, but the mechanism of action is unknown. This study tested the hypothesis that in patients with cGVHD, ECP modulates alloreactivity by affecting activated lymphocyte populations or by alteri...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 1998
ISSN: 1083-8791
DOI: 10.1016/s1083-8791(98)90007-6