Extracellular Mitochondria in Cerebrospinal Fluid and Neurological Recovery After Subarachnoid Hemorrhage

MicroRNA Changes in Cerebrospinal Fluid After Subarachnoid Hemorrhage

BACKGROUND AND PURPOSE Delayed cerebral ischemia (DCI) accounts for a major part of the morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). MicroRNAs (miRNAs) are pathophysiologically involved in acute cerebral ischemia. This study compared miRNA profiles in cerebrospinal fluid from neurologically healthy patients, as well as SAH patients with and without subsequent developm...

Thrombin activity in cerebrospinal fluid after subarachnoid hemorrhage.

Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage.

BACKGROUND AND PURPOSE The purpose of this study was to investigate changes in the cerebrospinal fluid sphingolipid profile in patients with subarachnoid hemorrhage in relation to the occurrence of symptomatic vasospasm and outcome at hospital discharge. METHODS The ceramide profile in the cerebrospinal fluid was determined by mass spectrometry in control subjects and patients with Fisher 3 g...

Lumbar Drainage of Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage

Background and Purpose—A single-center prospective randomized controlled trial has been conducted to determine if lumbar drainage of cerebrospinal fluid after aneurysmal subarachnoid hemorrhage reduces the prevalence of delayed ischemic neurological deficit and improves clinical outcome. Methods—Patients with World Federation of Neurological Surgeons Grade 1 to 3 aneurysmal subarachnoid hemorrh...

Cerebrospinal Fluid of Patients With Communicating Hydrocephalus After Subarachnoid Hemorrhage

Background and Purpose Transforming growth factor-/31 (TGF-/31) is a multifunctional polypeptide that controls the production of extracellular matrix protein. Platelets store a large quantity of TGF-/31, which is released at hemorrhage. We recently reported that human recombinant TGF-/31 induced communicating hydrocephalus in mice. The aim of this study was to determine whether TGF-01 is relate...