Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma
نویسندگان
چکیده
منابع مشابه
Neutrophil extracellular traps
Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer biology and tumor progression may prove much more than an unfortunate side effect of cancer.
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Neutrophil extracellular traps represent a fascinating mechanism by which PMNs entrap extracellular microbes. The primary purpose of this innate immune mechanism is thought to localize the infection at an early stage. Interestingly, the ability of different microcrystals to induce NET formation has been recently described. Microcrystals are insoluble crystals with a size of 1-100 micrometers th...
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Malaria is transmitted by mosquitoes and kills 2,000 humans in sub-Saharan Africa each day (1). Most of the victims are children younger than 5 years of age. Out of the five plasmodium species causing malaria, Plasmodium falciparum is responsible for most of the severe and fatal infections (2). Upon feeding, the female Anopheles mosquito inoculates sporozoites that seek out the hosts’ liver wit...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2019
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.201810-1869oc