منابع مشابه
Extracellular chaperones and proteostasis.
There exists a family of currently untreatable, serious human diseases that arise from the inappropriate misfolding and aggregation of extracellular proteins. At present our understanding of mechanisms that operate to maintain proteostasis in extracellular body fluids is limited, but it has significantly advanced with the discovery of a small but growing family of constitutively secreted extrac...
متن کاملRibosome-associated chaperones act as proteostasis sentinels
*Correspondence to: Richard I. Morimoto; Email: [email protected] Submitted: 05/30/2013; Accepted: 06/03/2013 http://dx.doi.org/10.4161/cc.25703 Comment on: Kirstein-Miles J, et al. EMBO J 2013; 32:1451-68; PMID:23604074; http://dx.doi.org/10.1038/emboj.2013.87 The production of newly synthesized proteins is a key process of protein homeostasis that initiates the biosynthetic flux of ...
متن کاملExtracellular chaperones.
The maintenance of the levels and correct folding state of proteins (proteostasis) is a fundamental prerequisite for life. Life has evolved complex mechanisms to maintain proteostasis and many of these that operate inside cells are now well understood. The same cannot yet be said of corresponding processes in extracellular fluids of the human body, where inappropriate protein aggregation is kno...
متن کاملMolecular chaperones and proteostasis regulation during redox imbalance☆
Free radicals originate from both exogenous environmental sources and as by-products of the respiratory chain and cellular oxygen metabolism. Sustained accumulation of free radicals, beyond a physiological level, induces oxidative stress that is harmful for the cellular homeodynamics as it promotes the oxidative damage and stochastic modification of all cellular biomolecules including proteins....
متن کاملRibosome-associated chaperones as key players in proteostasis.
De novo protein folding is delicate and error-prone and requires the guidance of molecular chaperones. Besides cytosolic and organelle-specific chaperones, cells have evolved ribosome-associated chaperones that support early folding events and prevent misfolding and aggregation. This class of chaperones includes the bacterial trigger factor (TF), the archaeal and eukaryotic nascent polypeptide-...
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ژورنال
عنوان ژورنال: Annual Review of Biochemistry
سال: 2013
ISSN: 0066-4154,1545-4509
DOI: 10.1146/annurev-biochem-072711-163904