EXTRA-NODAL PULMONARY MARGINAL ZONE LYMPHOMA ASSOCIATED WITH SJÖGREN DISEASE

TOPIC: Lung Cancer TYPE: Fellow Case Reports INTRODUCTION: Mucosal-associated lymphoid tissue (MALT), is a system of found within various organs that plays role in regulating local immunity. As this contains T, B, and plasma cells, it the potential site for development lymphoma. MALT lymphomas are form B-cell extranodal lymphoma can originate from marginal zone lymphocytes lung, referred to as pulmonary (PMZL). CASE PRESENTATION: We present 42-year-old female our clinic evaluation nodules mediastinal adenopathy. She had one year history Sjogren's syndrome. At time she no or B symptoms. To evaluate her adenopathy, was endobronchial ultrasound where pathologic revealed only polymorphous population negative malignancy. several hypervascular polypoid mainstem airways. Pathology these demonstrated an atypical infiltrate, but unable be characterized any further.Given ongoing concern lymphoproliferative process, video-assisted thoracoscopic surgery (VATS). left upper lower lobar wedge resections follicular bronchiolitis. Biopsy pleural nodule process concerning low-grade neoplasm, thought PMZL. oncology PET/FDG hypermetabolic multi-station adenopathy suggesting stage IV disease. Given asymptomatic nature anticipated indolent course, decided defer chemotherapy pending resolution COVID-19 pandemic. DISCUSSION: develop response continuous antigen stimulation, seen syndrome tobacco use. Radiographic features numerous, including consolidations, nodules, masses being most frequent patterns observed ~50% patients. Endobronchial lesions patient occur ~85% cases. imaging commonly demonstrates mild uptake identifiable lesions. It has very favorable prognosis with overall 5-year survival 90% due its excellent rate chemoimmunotherapy, typically combination Bendamustine Rituximab. CONCLUSIONS: uncommon neoplasm chronic especially patients numerous radiographic features, common When given clinical establishing diagnosis utmost importance therapy long-term prognosis. REFERENCE #1: Borie R, Wislez M, Thabut G, et al. Clinical characteristics prognostic factors Eur Respir J. 2009;34(6):1408-1416. #2: Husnain Kuker Reis IM, radiological lymphoma: A single center analysis. Med. 2020;9(14):5051-5064. #3: Stefanovic A, Morgensztern D, Fong Lossos IS. Pulmonary centre experience review SEER database. Leuk Lymphoma. 2008;49(7):1311-1320. DISCLOSURES: No relevant relationships by Brandon Jakubowski, source=Web Response Rosechelle Ruggiero,