Extra-Lysosomal Localization of Arylsulfatase B in Human Colonic Epithelium
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چکیده
منابع مشابه
Extra-lysosomal localization of arylsulfatase B in human colonic epithelium.
The enzyme arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB; ASB) removes 4-sulfate groups from the sulfated glycosaminoglycans (sGAG) chondroitin-4-sulfate (C4S) and dermatan sulfate (DS). Inborn deficiency of ARSB leads to the lysosomal storage disease mucopolysaccharidosis VI, characterized by accumulation of sGAG in vital organs, disruption of normal physiological processes, severe ...
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The human sulfatase family has 17 members, 13 of which have been characterized biochemically. These enzymes specifically hydrolyze sulfate esters in glycosaminoglycans, sulfolipids, or steroid sulfates, thereby playing key roles in cellular degradation, cell signaling, and hormone regulation. The loss of sulfatase activity has been linked to severe pathophysiological conditions such as lysosoma...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 2011
ISSN: 0022-1554,1551-5044
DOI: 10.1369/0022155410395511