Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
نویسندگان
چکیده
منابع مشابه
Geldanamycin inhibits trichostatin A-induced cell death and histone H4 hyperacetylation in COS-7 cells.
As widely believed treating cells with trichostatin A (TSA), an inhibitor of histone deacetylase, results in histone H4 hyperacetylation and cell cycle arrest. This compound is often compared with other potential anticancer drugs in cell cycle, proliferation and differentiation research. Furthermore, geldanamycin (GA), a 90-kDa heat shock protein (HSP90) specific inhibitor, is a well-known pote...
متن کاملHistone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells
Granzyme A (GzmA) was first identified as a cytotoxic T lymphocyte protease protein with limited tissue expression. A number of cellular proteins are known to be cleaved by GzmA, and its function is to induce apoptosis. Histones H1, H2B, and H3 were identified as GzmA substrates during apoptotic cell death. Here, we demonstrated that histone H4 was cleaved by GzmA during staurosporine-induced c...
متن کاملInducing cell death in Glioblastoma
Background Glioblastoma is the most common primary malignant brain tumor, and despite multimodal treatment with surgery, radiotherapy, and temozolomide (TMZ) chemotherapy, the prognosis is poor, with a median survival of 16 to 19 months [1]. Therefore, alternative treatments are necessary. A therapy anticipated to be one of the most effective anticancer treatments is tumor necrosis factor-relat...
متن کاملCarfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses.
PURPOSE Carfilzomib, while active in B-cell neoplasms, displayed heterogeneous response in chronic lymphocytic leukemia (CLL) samples from patients and showed interpatient variability to carfilzomib-induced cell death. To understand this variability and predict patients who would respond to carfilzomib, we investigated the mechanism by which carfilzomib induces CLL cell death. EXPERIMENTAL DE...
متن کاملCardiac glycosides exert anticancer effects by inducing immunogenic cell death.
Some successful chemotherapeutics, notably anthracyclines and oxaliplatin, induce a type of cell stress and death that is immunogenic, hence converting the patient's dying cancer cells into a vaccine that stimulates antitumor immune responses. By means of a fluorescence microscopy platform that allows for the automated detection of the biochemical hallmarks of such a peculiar cell death modalit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2019
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-019-1167-6