Extension of mouse lifespan by overexpression of catalase
نویسندگان
چکیده
منابع مشابه
Extension of murine life span by overexpression of catalase targeted to mitochondria.
To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria (MCAT). Median and maximum life spans were maximally increased (averages of 5 months and 5.5 months, respectively) in MCAT animals. Cardiac pathology and cataract development were delayed, oxidative damage...
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ژورنال
عنوان ژورنال: AGE
سال: 2006
ISSN: 0161-9152,1574-4647
DOI: 10.1007/s11357-006-9010-z