Extending Barrett’s esophagus cancer risk profile towards genetic abnormalities

Interaction of genetic variants towards increased cancer risk.

Genetic polymorphism in ERCC5 and breast cancer risk

ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...

Genetic polymorphism in ERCC5 and breast cancer risk

ERCC5 plays crucial role in excision repair DNA damage induced by UV in NER pathway. Single neuleotide polymorphism in ERCC5 were responsible for different cancers.Therefore, current study evaluated the relationship between ERCC5 (rs1047768 T>C) polymorphism and the risk of breast cancer in Pakistani population. The rs1047768 polymorphism was screened among 175 female...

D-GRIP: DNA Genetic Risk Information Profile

New genotyping technologies are producing reliable results with far greater coverage and at dramatically lower cost than previously possible. Given the rapid new discovery of disease associated markers and the new technology for determining the nucleotide sequences of key positions in the DNA of an individual, it is now feasible to apply existing knowledge to generate personalized analyses of g...

Risk of mortality and cancer incidence in Barrett's esophagus.

BACKGROUND There are very few prospective follow-up studies of Barrett esophagus (BE) cohorts assessing the risk of extraesophageal cancer incidence or mortality. Such studies are necessary in order to understand the overall risks of cancer and death experienced by patients with BE. METHODS A cohort of 502 patients with BE were identified at Leeds General Infirmary, England. Mortality and can...