منابع مشابه
High-throughput molecular dynamics simulations: Long and short range effects of mutations on substrate specificity
How do enzymes achieve substrate specificity? More specifically, how do structural elements and individual residues contribute to substrate recognition? Serine βlactamases are an interesting model to study the effect of exchange of individual residues on specificity because new enzyme variants with extended substrate spectra are a major cause of increasing antibiotic resistance of pathogenic ba...
متن کاملInducible and Plasmid Mediated AmpC Beta-Lactamase among Klebsiella pneumoniae in a Tertiary Care Teaching Hospital of South India
Amp C beta-lactamases are a type of cephalosporinase enzymes belonging to Class C of Ambler’s structural classification, while assigned to group 3 in the functional classification scheme of Bush (Ambler, 1980; Bush et al., 1995). These enzymes can be either chromosomal or plasmid encoded conferring resistance to both oxyimino (cefotaxime, ceftazidime, ceftriaxone) and 7-α methoxy cephalosporins...
متن کاملHigh Prevalence of Extended-Spectrum β-Lactamase Producing Enterobacteriaceae Among Clinical Isolates From Cats and Dogs Admitted to a Veterinary Hospital in Switzerland
Citation: Zogg AL, Simmen S, Zurfluh K, Stephan R, Schmitt SN and Nüesch-Inderbinen M (2018) High Prevalence of Extended-Spectrum β-Lactamase Producing Enterobacteriaceae Among Clinical Isolates From Cats and Dogs Admitted to a Veterinary Hospital in Switzerland. Front. Vet. Sci. 5:62. doi: 10.3389/fvets.2018.00062 high Prevalence of extendedspectrum β-lactamase Producing enterobacteriaceae amo...
متن کاملAlternatives to Ciprofloxacin Use for Enteric Fever, United Kingdom
intestinal, and respiratory tracts, as well as wounds; bloodstream infection is associated with higher death rates than infection at other sites (4). Hand carriage is probably the biggest factor in transmission of extendedspectrum β-lactamase producers, and there is little evidence to suggest that carriers of carbapenemase-producing K. pneumoniae would be different. Environmental contamination ...
متن کاملJapanese Encephalitis Outbreak, Yuncheng, China, 2006
1. Paterson DL, Bonomo RA. Extendedspectrum beta-lactamases: a clinical update. Clin Microbiol Rev. 2005;18: 657–86. 2. Livermore DM, Canton R, Gniadkowski M, Nordmann P, Rossolini GM, Arlet G, et al. CTX-M: changing the face of ESBLs in Europe. J Antimicrob Chemother. 2007; [Epub 2006 Dec 6]. 3. Pitout JD, Gregson DB, Church DL, Elsayed S, Laupland KB. Community-wide outbreaks of clonally rela...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2005
ISSN: 1058-4838,1537-6591
DOI: 10.1086/430789