Expression pattern of matrix metalloproteinases-2 and -9 and their tissue inhibitors in patients with chronic inflammatory demyelinating polyneuropathy

Matrix metalloproteinases (MMPs) are a heterogeneous family of endopeptidases that play role in many physiological functions, including the immune response. An imbalance between activity MMPs and their tissue inhibitors (TIMPs) has been proposed pathophysiology different autoimmune disorders. We aimed to assess plasmatic levels MMP-2, MMP-9, TIMP-1 -2 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Twenty CIDP 20 age- sex-matched healthy controls were enrolled. Plasma concentrations TIMP-1, TIMP-2 determined by enzyme-linked immunosorbent assay. subjects had higher MMP-9 along downregulation when compared controls, consequent increase MMP-9/TIMP-1 ratio (p<0.000002 for all measures). Conversely, concentration MMP-2 was lower group (p<0.01) without changes concentration. The MMP-2/TIMP-2 decreased patients’ (p<0.02). provide first preliminary evidence pattern TIMPs is markedly altered CIDP. Future studies needed potential usefulness these new biomarkers clinical setting.