Expression of TNF-α in oral cancer: A prospective diagnostic and prognostic molecular biomarker

TNF-α is a multifunctional cytokine that regulates cell proliferation and differentiation, as well immunological host defense responses to infection. It also induces angiogenesis, modulates tissue remodeling, controls apoptosis.TNF-α pleiotropic, pro-inflammatory has the potential be both pro-tumorigenic anti-tumorigenic. can cytotoxic tumour cells, slowing progression or causing necrosis, it enhance proliferation, migration, survival of cells in oral cancer cells. Several research studies clearly imply its soluble receptors could effective detecting, staging, predicting prognosis variety malignancies, including tumours. Well many were conducted detect actual response TNF- α, but lack knowledge understanding true towards precancer