Expression of the metastasis suppressor gene KISS1 in uveal melanoma
نویسندگان
چکیده
منابع مشابه
Expression of the metastasis suppressor BRMS1 in uveal melanoma
AIMS To determine the expression of breast metastasis suppressor 1 (BRMS1) in human uveal melanoma (UM) tissues and cell lines. In addition, we intend to establish a possible association between BRMS1 expression and the presence of metastatic disease. METHODS Thirty-one formalin-fixed paraffin-embedded tissues from enucleated eyes of patients with UM were immunostained. Clinical-pathological ...
متن کاملExpression of the Metastasis Suppressor KAI1 in Uveal Melanoma
Introduction. Uveal melanoma (UM) is an intraocular tumor that leads to metastatic disease in approximately 50% of afflicted patients. There is no efficacious treatment for metastatic disease in this cancer. Identification of markers that can offer prognostic and therapeutic value is a major focus in this field at present. KAI1 is a metastasis suppressor gene that has been reported to play a ro...
متن کاملThe metastasis suppressor KISS1 lacks antimetastatic activity in the C8161.9 xenograft model of melanoma.
The objective of this study was to use the established xenograft model of human melanoma (C8161.9) to test a pharmacological approach to the effect of the metastasis suppressor KISS1. A KISS1 analog was used to inhibit the metastatic development of C8161.9 cells in nude mice. Further experiments were performed to test the validity of the C8161.9 model and test the connection between KISS1 expre...
متن کاملUveal Melanoma Metastasis Models.
Metastatic disease is the leading cause of death among patients with uveal melanoma. Treatment options for patients with clinically disseminated disease are usually unsuccessful. In vitro and in vivo models are important tools to investigate the pathogenesis of metastatic uveal melanomas and develop treatments for the metastases. In vitro experimental approaches focusing on cell invasion/migrat...
متن کاملEpigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma.
Metastatic melanoma is a fatal disease due to the lack of successful therapies and biomarkers for early detection and its incidence has been increasing. Genetic studies have defined recurrent chromosomal aberrations, suggesting the location of either tumor suppressor genes or oncogenes. Transcription factor 21 (TCF21) belongs to the class A of the basic helix-loop-helix family with reported fun...
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ژورنال
عنوان ژورنال: Eye
سال: 2008
ISSN: 0950-222X,1476-5454
DOI: 10.1038/sj.eye.6703090