Expression of sugar chain antigen CA15-3 (DF3) in extramammary Paget's disease tumor cells.

Diagnostic value of cancer antigen 15-3 (CA15-3) detected by monoclonal antibodies (115D8 and DF3) in exudative pleural effusions.

Pleural fluid levels of the cancer antigen 15-3 (CA15-3) detected by monoclonal antibodies (115D8 and DF3) were determined in 40 patients with carcinomatous pleural effusions and in 41 patients with tuberculous pleural effusions. Using a cut off level of 16 U/ml, 15 of the 40 carcinomatous fluids but none of the 41 tuberculous fluids were positive. Pleural fluid levels of CA15-3 were not correl...

Prognostic Significance of Circulating Tumor Cells and Serum CA15-3 in Metastatic Breast Cancer

Breast cancer (BC) is the second leading cancer causing death in women (Siegel et al., 2012). Despite the widespread use of the screening methods, 5% of the cases were diagnosed at the advanced stage. Spread of the BC cells native of the primary location through circulation is one cause leading to metastasis (Jacob et al., 2007; Fehm et al., 2008). Presence of the circulating tumor cells (CTC) ...

Frequent alteration of the DF3 tumor-associated antigen gene in primary human breast carcinomas.

The gene for the human DF3 breast carcinoma-associated antigen contains a conserved (G + C)-rich 60-base pair tandem repeat and maps to chromosome 1q21-24. In the present study we isolated and characterized 1220 base pairs of nonrepetitive adjacent sequences. Multiple alleles were identified by fragment size. Signal intensity of hybrids with the tandem and unique sequence probes indicated that ...

Pagets Disease Of The Nipple

Expression of Prostate-Specific Membrane Antigen (PSMA) in Brain Glioma and its Correlation with Tumor Grade

Background & Objective Angiogenesis is an essential component of tumor growth. Expression of PSMA on the neo-vasculature of many solid tumors, including glioblastoma multi-form, has been determined. The pattern of expression suggests that PSMA may play a functional role in angiogenesis. Methods: expression of PSMA in dif...