Expression of Integrin β1, Focal Adhesion Kinase, and PDZ-Binding Motif in Human Liver Cirrhosis and Simple Steatosis

Background: Integrins are transmembrane mechanosensitive proteins that negatively contribute to the pathogenesis of different types chronic liver disease and can activate focal adhesion kinase (FAK). Objectives: This study aimed determine hepatic integrin β1 FAK mRNA as well transcriptional coactivator with PDZ-binding motif (TAZ) protein expressions in cirrhotic patients simple steatosis. Methods: In this case–control study, tissues were collected from 30 various etiologies (i.e., nonalcoholic steatohepatitis-, primary sclerosing cholangitis-, alcoholic-, autoimmune hepatitis [AIH]- B virus [HBV]/hepatitis C [HCV]-related cirrhosis [six per group]), samples steatosis (n=6), control (n=9). Results: Integrin gene expression was significantly up-regulated all groups compared group (P<0.05), exception AIH cirrhosis. However, TAZ level not than those group. Furthermore, lower steatohepatitis (NASH) (P<0.05). Conclusion: tissues. addition, FAK, β1, concordantly down-regulated steatosis, may have been involve development.