Expression of Her-2/neu in extrahepatic cholangiocarcinoma
نویسندگان
چکیده
منابع مشابه
Adjuvant surgery for advanced extrahepatic cholangiocarcinoma.
Patients with Stage IV cholangiocarcinoma are currently not considered to be surgical candidates and are typically offered systemic chemotherapy. Recently, several novel systemic chemotherapy regimens have allowed an initially unresectable cholangiocarcinoma to be resectable. The aim of this article is to present the usefulness of adjuvant surgery in a case of advanced cholangiocarcinoma that w...
متن کاملExpression of peptidyl-prolyl isomerase PIN1 and its role in the pathogenesis of extrahepatic cholangiocarcinoma
The phosphorylation of proteins on serine/threonine residues that immediately precede proline (pSer/Thr-Pro) is a key signaling mechanism by which cell cycle regulation and cell differentiation and proliferation occur. The peptidyl-prolyl isomerase PIN1-catalyzed conformational changes of the pSer/Thr-Pro motifs may have profound effects on the function of numerous oncogenic and cell signaling ...
متن کاملPathological significance of IgG4-positive plasma cells in extrahepatic cholangiocarcinoma
*KURAに登録されているコンテンツの利用については,著作権法に規定されている私的使用や引用などの範囲内で行ってください。 *著作権法に規定されている私的使用や引用などの範囲を超える利用を行う場合には,著作権者の許諾を得てください。ただし,著作権者 から著作権等管理事業者(学術著作権協会,日本著作出版権管理システムなど)に権利委託されているコンテンツの利用手続については ,各著作権等管理事業者に確認してください。 Title Pathologic significance of immunoglobulin G4-positive plasma cells in extrahepatic cholangiocarcinoma Author(s) Kimura, Yasushi; Harada, Kenichi; Nakanuma, Yasuni Citation Human Path...
متن کاملThe expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma.
PURPOSE The protein kinase B (AKT) pathway plays a key role in the regulation of cellular survival, apoptosis, and protein translation, and has been shown to have prognostic significance in a number of cancers. We sought to define its role in extrahepatic cholangiocarcinoma. EXPERIMENTAL DESIGN Two hundred twenty-one extrahepatic cholangiocarcinoma patients with clinicopathologic data, includ...
متن کاملGeographic Variation of Intrahepatic Cholangiocarcinoma, Extrahepatic Cholangiocarcinoma, and Hepatocellular Carcinoma in the United States
BACKGROUND Intrahepatic (ICC) and extrahepatic cholangiocarcinomas (ECC) are tumors that arise from cholangiocytes in the bile duct, but ICCs are coded as primary liver cancers while ECCs are coded as biliary tract cancers. The etiology of these tumors is not well understood. It has been suggested that the etiology of ICC is more similar to that of another type of liver cancer, hepatocellular c...
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ژورنال
عنوان ژورنال: Pathology and Laboratory Medicine International
سال: 2017
ISSN: 1179-2698
DOI: 10.2147/plmi.s116947