Expression of galectin-3 in gonads and gonadal sex cord stromal and germ cell tumors

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Expression of galectin-3 in gonads and gonadal sex cord stromal and germ cell tumors.

Galectin-3, a beta-galactoside-binding lectin, has been implicated in many human malignancies, but has seldom been studied in human gonads and gonadal tumors. The aim of our study was to investigate galectin-3 mRNA and protein expression in normal ovaries and testes as well as in a variety of 51 gonadal sex cord stromal and germ cell tumors, and two testicular seminomatous and non-seminomatous ...

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Evaluation of galectin-3 expression in ameloblastoma stromal fibroblasts and its association with recurrence

Introduction: Ameloblastoma is a benign odontogenic neoplasm with a high risk of recurrence. Ameloblastoma stromal fibroblasts are associated with tumor growth and invasion; however, a few studies have evaluated the immunohistochemical characteristics of stromal fibroblasts and their association with recurrence in Ameloblastoma. Galectin-3 (gal-3) is a member of the B-galactoside bonding protei...

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N-cadherin Expression in Testicular Germ Cell and Gonadal Stromal Tumors

Neural-cadherin is a member of the cadherin gene family encoding the N-cadherin protein that mediates cell adhesion. N-cadherin is a marker of Sertoli cells and is also expressed in germ cells of varying stages of maturation. The purpose of this study was to determine the presence and distribution of this protein by immunohistochemistry in 105 germ cell tumors of both single and mixed histologi...

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Ovary: Sex cord-stromal tumors

There appear to be several established clinical syndromes associated with several subtypes of sex cord-stromal tumours. 30% of patients with sex cord tumours with annular tubules have Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterised by multiple gastrointestinal hamartomatous polyps, increased risk of various neoplasms, and melanocytic macules of the lips, buccal mucosa...

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Gonadal germ cell tumors in children

BACKGROUND The true incidence of gonadal germ cell tumors (GCTs) in children is unknown. Few studies have been published concerning about pediatric gonadal GCTs. The aim of this study is to review and analyze clinical data on the diagnosis and management of gonadal GCTs in children. METHODS Between 2005 and 2015, 127 pediatric patients (<14 years old) with gonadal GCTs admitted to our institu...

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ژورنال

عنوان ژورنال: Oncology Reports

سال: 2006

ISSN: 1021-335X,1791-2431

DOI: 10.3892/or.16.2.335