Expression of extracellular superoxide dismutase in the human male reproductive tract, detected using antisera raised against a recombinant protein
نویسندگان
چکیده
منابع مشابه
Expression of extracellular superoxide dismutase in the human male reproductive tract, detected using antisera raised against a recombinant protein.
Mammalian spermatozoa are particularly susceptible to the deleterious effects of reactive oxygen species and lipid peroxidation, which ultimately lead to impaired fertility. A number of enzymes are present in the male reproductive tract which may play a role in preventing oxidative damage; in particular, the epididymis is the site of synthesis and secretion of large amounts of extracellular sup...
متن کاملP-17: Expression of Cell Surface Toll-Like Receptors in the Human Male Reproductive Tract
Background: Male infertility refers to the inability of a male to achieve a pregnancy in a fertile female. The root of many causes of infertility is miscommunication between immune and reproductive system. Male reproductive system is very sensitive and vulnerable, infections can hinder maturation and movement of spermatozoa lead to impaired fertility.All species need an immediate reply to the m...
متن کاملEvaluating the Effect of Protein A Signal Peptide on Extracellular Expression of Recombinant Hirudin in E.Coli
Abstract Background and Objective: Hirudin is an anticoagulant polypeptide secreted from the salivary glands of leeches. Recombinant hirudin is a strong anticoagulant agent in arterial and venous thrombosis. The aim of this study was to evaluate the effect of inserting protein A signal peptide sequence of pEZZ18 plasmid on expression and secretion...
متن کاملExpression of Extracellular Superoxide Dismutase Protein in Diabetes
BACKGROUND Diabetes is characterized by chronic hyperglycemia, which can increase reactive oxygen species (ROS) production by the mitochondrial electron transport chain. The formation of ROS induces oxidative stress and activates oxidative damage-inducing genes in cells. No research has been published on oxidative damage-related extracellular superoxide dismutase (EC-SOD) protein levels in huma...
متن کاملExpression of Extracellular Superoxide Dismutase in Atherosclerosis
We characterized a novel form of extracellular superoxide dismutase (ecSOD) in atherosclerotic vessels. Specific activity and protein expression of ecSOD was increased twoto threefold in apo E–deficient compared with control aortas. RNase protection assays demonstrated that the expected ecSOD transcript was not increased in either apo E–deficient mice or cholesterol-fed LDL receptor–deficient m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 1998
ISSN: 1460-2407
DOI: 10.1093/molehr/4.3.235