Expression of apoptosis-related proteins in experimental coxsackievirus myocarditis

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Expression of apoptosis-related proteins in experimental coxsackievirus myocarditis.

OBJECTIVE The extent to which apoptosis contributes to myocyte cell loss during acute carditic viral infection is unknown. To assess whether apoptosis occurs in acute viral myocarditis, and how it is modulated, we studied mice inoculated with coxsackievirus B3 (CVB3). METHODS Five CD1 and C3H.HeJ (C3H) mice/group were sacrificed as saline vehicle-injected controls, and at 1, 2, and 3 weeks po...

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Virus receptor trap neutralizes coxsackievirus in experimental murine viral myocarditis.

OBJECTIVE The coxsackie and adenovirus receptor (CAR) and the decay-accelerating factor (DAF) are receptors for coxsackievirus B3 (CVB3), which is known as the major cause of human viral myocarditis. We investigated the potential for therapeutic use of soluble virus receptor fusion proteins. METHODS We designed and generated a novel virus receptor trap (hCAR-hDAF:Fc) consisting of both CVB3 r...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 1998

ISSN: 0008-6363

DOI: 10.1016/s0008-6363(97)00323-4